Sabinsa Corp., Piscataway, NJ, has secured U.S. Patent No. 7,253,324, protecting the process for the synthesis of biologically active polyphenolic compounds by novel dealkylation. This process of aromatic poly o-demethylation is applicable in the manufacturing of polyphenols, such as resveratrol, oxy­resveratrol and gnetol. This patent covers a wide range of applications in the multi-step synthesis of pharmaceuticals and fine chemicals. This streamlined manufacturing process enables easy access to several known polyphenols and simplifies the course of action for discovering unknown polyphenolic compounds.